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Hypotonia causes

Causes of hypotonia - News Medica

Other causes of hypotonia include: Cerebral palsy Storage diseases - Inherited metabolic diseases that are caused due to lack of certain enzymes. Congestive Heart failure Hypoglycemia - Low blood sugar may lead to floppiness of the muscles Myasthenia gravis - is an autoimmune disease that disrupts. Hypotonia is the result because the larger muscles are unable to provide adequate tension or resistance to the movement because the bones are disproportionally too short. Get familiar with more causes of hypotonia now. Encephalitis HealthImaging. Encephalitis in an individual can cause them to develop hypertonia Rarely, hypotonia is caused by botulism infections or contact with poisons or toxins. However, the hypotonia often goes away after you recover It can be caused by a number of different underlying health problems, many of which are inherited. Hypotonia can also sometimes occur in those with cerebral palsy, where a number of neurological (brain-related) problems affect a child's movement and co-ordination, and after serious infections, such as meningitis Muscles Tone refers to the amount of muscle-fiber tension in individual muscles or muscle groups. Hypotonia (also known as Poor Muscle Tone or Floppy Baby Syndrome) is a term used to describe a reduction in muscle tone. The muscles of those who suffer from this condition display a remarkably low resistance to movement and stretchin

Hypotonia can happen from damage to the brain, spinal cord, nerves, or muscles. The damage can be the result of trauma, environmental factors, or genetic, muscle, or central nervous system disorders. For example, it can be seen in Down syndrome, muscular dystrophy, cerebral palsy, Prader-Willi syndrome, myotonic dystrophy, and Tay-Sachs disease Some conditions known to cause hypotonia include: Congenital - i.e. disease a person is born with (including genetic disorders presenting within 6 months) Genetic disorders are the most common cause 22q13 deletion syndrome a.k.a. Phelan-McDermid syndrome; 3-Methylcrotonyl-CoA carboxylase deficiency; Achondroplasia; Aicardi syndrom

Conditions That Can Cause Hypotonia (Low Muscle Tone

Hypotonia (Muscle Weakness): Signs, Causes, and Treatment

Hypotonia - NH

The most common cause of hypotonia is abnormalities in neurological control of muscle tone. Muscles need electrical signals from motor nerves for functioning. Any disruption in the signal generation or conduction may affect the muscle tone. Various inherited conditions and other factors can cause hypotonia

Hypotonia is most often diagnosed during infancy (before the age of three) and may also be known as floppy infant syndrome or infantile hypotonia. Causes of Hypotonic Cerebral Palsy Acquired Hypotonic Cerebral Palsy - This type of cerebral palsy occurs when there is damage to the brain after the time of birth Central Hypotonia Definition; Is a condition of decreased muscle ton. Hypotonia can result from a many central or peripheral causes. Therefore, hypotonia is a phenotype of many clinical conditions with variable prognosis (1). Central hypotonia originates from the central nervous system, while peripheral hypotonia i This review focuses on the special case of diffuse hypotonia presenting in the neonatal period. Etiologies are broad and include systemic illness, dysfunction of the central nervous system, or dysfunction of the peripheral nervous system and motor unit (ranging from disorders of the anterior horn cell to primary muscle disease)

Hypotonia causes. Hypotonia are usually of unknown origin. Hypotonia can be caused by a variety of conditions, scientists believe that hypotonia may be caused by a variety of conditions such trauma that involve the central nervous system, environmental factors, genetic disorders and muscle disorders 4) Hypotonia, also called floppy infant syndrome or infantile hypotonia, is a condition of decreased muscle tone. The low muscle tone can be caused by a variety of conditions and is often indicative of the presence of an underlying central nervous system disorder, genetic disorder, or muscle disorder

Causes of Hypotonia Down's Syndrome. This falls under the hereditary category of disorders which cause hypotonia as one of its symptoms. Down's syndrome is a chromosomal abnormality seen it children and it is progressive.. In this disorder, the muscle integrity is maintained with the help of regular exercises and keeping the muscles active Causes of Hypotonia. Hypotonia is not a disease; it is a sign of a problem. But there could be many problems that cause hypotonia. Some disorders associated with hypotonia include Hypotonia management; Causes of Hypotonic brain disorder. To understand what causes hypotonus in people with brain disorder, it's essential to grasp the connection between the brain and muscles. Muscle tone is primarily regulated by the transmission of signals from the brain. These signals travel down the neural structure to the muscles. Hypotonia is a medical term used to describe decreased muscle tone. Normally, even when relaxed, muscles have a very small amount of contraction that gives them a springy feel and provides some resistance to passive movement. It is not the same as muscle weakness, although the two conditions can co-exist. Muscle tone is regulated by signals that travel from the brain to the nerves and tell the.

Hypotonia is now seen as a symptom, not a disease unto itself. Causes of hypotonia. There are a large number of causes for hypotonia. Some causes of hypotonia are genetic in nature while others are caused by infections, autoimmune disorders, metabolic disorders, and neurological injury CAUSES. The causes of hypotonia and weakness in infancy are diverse: Ill-appearing infant - Hypotonia may be part of an overall ill appearance of the infant. Infection is an important cause of ill appearance in infancy; other causes are summarized in the table . The approach to evaluating and managing ill-appearing infants is discussed.

Hypotonia: Causes, Symptoms, Diagnosis, and Treatment

It causes a rash on the body and seizures. 9) West Syndrome - This is a condition in which the brain develops a quick high-pitched pulse, a fast rate, and is very irritable. 10) Other - Other things that can cause hypotonia are: poor nutrition, lack of oxygen, head injury, poisoning, infection or an inherited trait Hypotonia management; Causes of Hypotonic Cerebral Palsy. To understand what causes hypotonia in individuals with cerebral palsy, it's critical to understand the relationship between the brain and muscles. Muscle tone is primarily regulated by the transmission of signals from the brain. These signals travel down the spinal cord to the muscles.

Hypotonia Information Page National Institute of

Hypotonia, also called floppy muscle syndrome, is a condition that involves the progressive loss of muscle tone over time. Some infants (birth to 1 year*) are born with hypotonia, and some children develop hypotonia as a symptom of another condition Kids With Hypotonia Have Their Diagnosis. This can get confusing but think of low tone as a symptom instead of a cause. It's the runny nose, not the common cold. Unless your child has benign congenital hypotonia, something else is responsible for the decreased muscle tone. Down syndrome, cerebral palsy, and genetic disorders are all examples Each child may experience different symptoms, depending on the underlying cause of the hypotonia: decreased muscle tone; muscles feel soft and doughy ability to extend limb beyond its normal limit failure to acquire motor skill developmental milestones (such as holding head up without support from.

Hypotonia - Wikipedi

Occasionally, an underlying disorder may be the cause of the hypotonia. If your child as an underlying condition, discuss this with your child's doctor. What is floppy baby syndrome? Floppy baby syndrome is not a syndrome at all. It is rather a way of describing a newborn baby with low muscle tone. The term 'syndrome' can be distressing for. Patients with central hypotonia generally have hypotonia without associated weakness, in contrast to the peripheral (lower motor neuron) causes, which typically produce both hypotonia and muscle weakness. Hypotonia is a clinical manifestation of over 500 genetic disorders; thus, a logical, stepwise approach to diagnosis is essential. With recen

What Is Hypotonia, or Floppy Infant Syndrome? Causes

  1. A decrease in muscle tone (hypotonia) A decrease in muscle power (weakness) Ligamentous laxity and an increased range of joint mobility ; What does the term hypotonia mean? It is defined as resistance to passive movement around the joint It's assessed in two ways by clinician
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  3. Causes of Hypotonia. Hypotonia can happen from damage to the brain, spinal cord, nerves, or muscles. The damage can be the result of trauma, environmental factors, or genetic, muscle, or central nervous system disorders
  4. Hyptonia Causes. There are two possible causes of hypotonia: vestibular issues and nutritional deficiencies (or both). Vestibular Issues. Occupational therapists contend that vestibular system imbalances are to blame for low muscle tone. The vestibular system is the primitive sensory system that is responsible for gravitational stability
Hypotonia (Floppy Infant Syndrome): Signs, Causes & Treatment

A schematic approach to hypotonia in infanc

  1. Causes of Peripheral Hypotonia in Assiut University Children Hospital The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government
  2. utes
  3. Down's syndrome: This is the most common cause of hypotonia. Aside form hypotonia, features of Down's Syndrome include a short neck, excess skin folds on back of neck, eyes that slant upwards.
  4. Treating Hypotonia. Outgoing teen Meredith Zanelotti has been able to remain active through management of her low muscle tone and underlying genetic disorder at the Johns Hopkins Hypotonia Center. Many patients with low muscle tone go undiagnosed and untreated for months or years, leaving parents feeling lost in a system with no real answers.
  5. Hypotonia is used to describe unusually low muscle tone, which causes floppiness in the muscles. This inability to regulate muscle tone is what causes CP symptoms. Athetoid CP can also result in issues surrounding voluntary movement in the hands, arms, feet and legs — making it hard to walk or grasp objects
  6. Hypotonia and how to assess muscle tone with the pediatric patient. The learner will be able to differentiate the common causes of Hypotonia in the pediatric patient. The learner will be able to perform an evaluation of a child with Hypotonia. The learner will develop a personal resourc
  7. Hypertonia is a term sometimes used synonymously with spasticity and rigidity in the literature surrounding damage to the central nervous system, namely upper motor neuron lesions. Impaired ability of damaged motor neurons to regulate descending pathways gives rise to disordered spinal reflexes, increased excitability of muscle spindles, and decreased synaptic inhibition

Hypotonia Causes of hypotonia - Zan

Children often are referred for physical therapy with the diagnosis of hypotonia when the definitive cause of hypotonia is unknown. The purpose of this case report is to describe the clinical decision-making process using the Hypothesis-Oriented Algorithm for Clinicians II (HOAC II) for an infant with hypotonia and gross motor delay Hypotonia causes. To function normally, muscles depend on signals from nerves called motor nerves. There are two types of hypotonia (decreased muscle tone) that can occur due to problems related to the motor nerves. These are described below Hypotonia: Part Two: Causes & Effects Causes. Never underestimate the passion of a parent looking for the cause of their child's medical concern. I constantly feel like I'm on CSI trying to discover who the bad guy is and all I have to work with are mixed up alibis and a hunch. Sure Down Syndrome is a suspect, but he was having dinner with.

Hypotonia - Symptoms, Causes and Treatment - Health Heart

Potential causes for hypotonia in Down syndrome. Virtually all papers on motor control, motor development, and motor learning in Down syndrome mention low muscle tone or hypotonia as a major contributor to the typical differences between movements performed by persons with and without Down syndrome [3,9-12] Hypotonia in neonates. Congenital hypotonia is a relatively common diagnosis in the newborn period. It is defined as a subjective decrease of resistance to passive range of motion in a newborn and can be due to a defect at any level of the nervous system. This document is only valid for the day on which it is accessed

Muscle Weakness (Hypotonia) Boston Children's Hospita

  1. Causes and Diagnosis. Some metabolic disorders are associated with hypotonia. Strabismus (crossed eyes) and seizures can be associated with hypotonia in metabolic disorders. Children who have autism, developmental delays and hypotonia may need to be evaluated for inborn errors of metabolism
  2. What Is Hypotonia? Hypotonia is a decreased level of muscle tone. Kids on this end of the spectrum are described as limp and floppy. Their muscles are too relaxed. This can impact everything from walking to eating to potty training. What Causes Hypotonia? Low muscle tone is often, but not exclusively, linked to some sort of chromosomal abnormality
  3. al pain, lethargy, polyuria, dehydration, failure to thrive, and seizures. In severe cases renal failure, pancreatitis and reduced consciousness may also occur and older children and adolescents may present with psychiatric symptoms
  4. causes of hypotonia • List common causes for neonatal hypotonia • Order appropriate initial investigations for the common causes of neonatal hypotonia. Case Presentation Let's start with a clinical case. You are a learner doing a rotation in the Neonatal Intensive Care Unit. Your preceptor tells you that there is a 2-day-old who was found t
  5. ate other causes of.

Low Muscle Tone or HypotoniaCausesSymptomsTreatment

  1. g fine and gross motor activities that require coordinated, controlled movements like.
  2. always have hypotonia, but hypotonia may exist without weakness. Because dysfunction at any level of the nervous system can cause hypotonia, the differential diagnosis is extensive. Central causes, both acute and chronic, are more common than are peripheral disorders. Central conditions include hypoxic-ischemic encephalopathy
  3. Hypertonia is a condition in which there is too much muscle tone so that arms or legs, for example, are stiff and difficult to move. Muscle tone is regulated by signals that travel from the brain to the nerves and tell the muscle to contract
  4. Eventually, CIDP causes a significant loss of muscle reflexes. This is a long-term condition that can lead to worsening symptoms without treatment. Hypotonia is often temporary in most people.
  5. De novo, heterozygous, loss of function variants were identified in Pou domain, class 4, transcription factor 1 (POU4F1) via whole exome sequencing in four independent probands presenting with ataxia, intention tremor, and hypotonia. POU4F1 is expressed in the developing nervous system, and mice hom
  6. When those muscles have less tension, the joints are less supported by resting muscles. This means that a child must activate those muscles to get the same amount of joint support that a child with higher muscle tone gets by doing nothing at all. Children with low muscle tone have to work harder to stabilize their joints and move against gravity
  7. Suspect infant botulism in an infant younger than 6 months of age who has signs and symptoms such as constipation, listlessness, poor feeding, weak cry, a de..

Hypotonia is a common presenting feature in a variety of congenital, metabolic, and neuromuscular disorders. The initial assessment and laboratory testing often suggest the etiology; however, in those infants who have a neuromuscular cause of hypotonia, the potential diagnoses have differing anesthetic implications Causes. Congenital myopathies are caused by one or more genetic abnormalities in genes that control muscle development. Risk factors. The only known risk factor for congenital myopathies is having a blood relative with one of these conditions, or one or both parents who carry a mutated gene that causes them From OMIM Hypotonia, ataxia, and delayed development syndrome (HADDS) is a neurodevelopmental syndrome characterized by congenital hypotonia, delayed psychomotor development, variable intellectual disability with speech delay, variable dysmorphic facial features, and ataxia, often associated with cerebellar hypoplasia. Some patients may have urogenital abnormalities (summary by Sleven et al. The main indicator of PWS in children aged younger than 1 year is severe hypotonia and FTT, as these are almost universal findings. 8,11-15 These findings, along with a characteristic fetal history, should prompt further workup. A chromosome 5q11-13 deletion, seen via DNA analysis, is diagnostic of PWS. 11 Hypotonia is a symptom and it can manifest due to several underlying causes. Hypotonia can be present since birth or may develop later during infancy. At birth it is regarded as congenital hypotonia where as if it is later on it is called acquired hypotonia. It can result from neurological diseases or muscular problems. Inheritance, injury and.

Causes of Hypotonia. Hypotonia may be caused by trauma, environmental factors, or by genetic, muscle, or central nervous system disorders. Down syndrome occurs when there is an extra copy of chromosome 21. This form of Down syndrome is called Trisomy 21. The extra chromosome causes problems with the way the body and brain develop Causes of hypotonia. Hypotonia may sometimes be caused by trauma, genetic heritage, muscle or central nervous system disorders, or because of the different environmental factors. However, for many cases the exact cause remains unknown. Certain health conditions may also be responsible for hypotonia: Down syndrome, infant botulism, cerebellar. Hypotonia is an abnormally severe loss of muscle tone. The muscles feel soft and doughy. Diagnosing the cause of hypotonia in a particular child is very difficult. Hypotonia is a symptom of many cerebral, spinal, genetic, or muscular diseases. Some of the diseases associated with hypotonia are Guillain-Barre syndrome, muscular dystrophy.

Hypotonia Or Floppy Infant Syndrome: Symptoms, Causes, And

Macrocephaly refers to an overly large head in infants. It is not a condition in itself, but it may be a symptom of other conditions or complications in the brain. There are certain factors that. Hypotonia - Causes, Signs and Treatment. 11:44 No comments. Hypotonia is more a description than a diagnosis. It is most often seen in newborns (congenital) and infants, but it may persist through adolescence into adulthood. Another name for infantile hypotonia is floppy baby syndrome. This refers to the tendency of a hypotonic infant's. infants with important causes of hypotonia, such as Trisomy 21 (Down syndrome) and prematurity, can be applied to the care of these infants. Trisomy 21, a genetic disorder where more than 90% of infants havehypotonia, sharesmanyofthesamefeeding risks and complicating morbidities as other causes of hypotonia Biotin deficiency in children is generally due to a genetic disorder known as biotinidase deficiency, which causes hypotonia, ataxia, hearing loss, optic atrophy, skin rash, and alopecia. Supplementation with biotin resolves these symptoms

The Floppy Infant American Academy of Pediatric

Causes Hypotonia can be caused by any one or a combination of various disorders. However, they can be broadly classified as follows: Genetic disorders that are the leading cause of hypotonia in infants. Krabbe Disease: A rare, fatal disease, it affects the nervous system and leads to progressive degeneration of nerve control and bodily. Causes. Gastrointestinal motility disorders may cause a wide range of digestive symptoms, including difficulty swallowing, gastroesophageal reflux disease (GERD), gas, severe constipation, diarrhea, abdominal pain, vomiting, and bloating. 1 . The problem with your digestive muscles can be due to one of two causes Causes of this type of hypotension include: Loss of blood from bleeding. Low body temperature. High body temperature. Heart muscle disease causing heart failure. Sepsis, a severe blood infection. Here, we report a patient with profound hypotonia, severe intellectual disability, and seizures who had biallelic loss-of-function variants in OTUD7A: a 15q13.3 deletion including the OTUD7A locus, and a frameshift OTUD7A variant c.1125del, p.(Glu375Aspfs*11). Unexpectedly, both aberrations occurred de novo

Approach to floppy infant

Hypotonia - an overview ScienceDirect Topic

Causes. While some causes for hypotonia are unknown, generally low muscle tone may be congenital or acquired. If it's congenital, it may be due to genetic, muscular or chromosomal disorders, such as Down's syndrome, muscular dystrophy or Tay-Sachs disease. Acquired hypotonia may be due to brain, spinal cord, nerve or muscle trauma/injury In severe cases of hypotonia, the muscles may be so weak that a child has difficulty sitting up for extended periods, chewing, or pushing out bowel movements. Milder cases, affecting the finger or eye muscles, cause fine motor delays or visual processing disorders. All children with hypotonia have reduced stamina. Symptoms Associated with Hypotonia Potential causes for hypotonia in Down syndrome 1) Viscoelastic properties of tendons and ligaments and inertia of body segments Assuming that a person is relaxed... 2) Ability to relax muscles crossing the joint This ability cannot be taken for granted. In some cases, such as... 3) Ability to avoid. INTRODUCTION. Hypotonia refers to an impairment that may be associated many different conditions, including those of neuromuscular, genetic, central nervous system, connective tissue, and/or metabolic origins. 1,2 Hypotonia is frequently mentioned as a component of disorders such as Down syndrome (DS), Prader-Willi syndrome, and cerebral palsy. 3-5 In other instances, hypotonia may be the. underlying cause of hypotonia in infants remains difficult,3 except in more common and widely recognized conditions, such as Down syndrome. Differentiating the likely causes of hypotonia is important to spare some infants from needless, invasive diagnostic tests, such as muscle biopsy, if the under

Treating hypotonia. Depending on the cause, hypotonia can improve, stay the same or get worse over time. Babies with hypotonia that results from being born prematurely will usually improve as they get older. Babies with hypotonia caused by an infection or another condition will usually improve if the underlying condition is treated successfully When your child's low muscle tone (hypotonia) goes unexplained, a rare genetic disorder may be the cause. This website provides information about one rare disorder called Aromatic L-amino Acid Decarboxylase (AADC) deficiency, which can cause hypotonia and other symptoms in children Background A syndrome of profound hypotonia, intellectual disability, intrauterine growth retardation with subsequent failure to thrive, dyskinesia and epilepsy was diagnosed in Bedouin Israeli families. Mild dysmorphism was evident: plagiocephaly, broad forehead with prominent nose, smooth philtrum and congenital esotropia. We set out to decipher the molecular basis of this syndrome Hypotonia, or Low Muscle Tone. Contra r y to Hypertonia, Hypotonia is a condition where children present very floppy, or flaccid muscular tone. This condition is more common than hypertonia in autism and is represented by having too little muscle tone i n their bodies

5 Home Physical Therapy Exercises for Low Muscle Tone

Multiple congenital anomalies-hypotonia-seizures syndrome is an autosomal recessive disorder characterized by neonatal hypotonia, lack of psychomotor development, seizures, dysmorphic features, and variable congenital anomalies involving the cardiac, urinary, and gastrointestinal systems. Most affected individuals die before 3 years of age. Soon after birth or during early infancy, the patients presented with hypotonia, feeding difficulties with episodic vomiting, sometimes requiring tube feeding, and global developmental delay. Six patients had congenital heart defects, including septal defects, valvular anomalies, hypoplastic aortic arch or coarctation, and tetralogy of Fallot Infant Hypotonia. Hypotonia is a medical condition characterized by poor muscle tone. In infants, it is more commonly known as floppy baby syndrome. Hypotonia can be a separate congenital disorder or it can be a symptom of another underlying condition such as cerebral palsy or muscular dystrophy. Hypotonia is typically diagnosed during infancy hypotonia. Hypotonia may originate from disturbances in the physiology of central or peripheral nervous systems or of the end organs themselves (muscles and muscle groups). The current pathway will only address children whose hypotonia is centrally-mediated and will exclude those whose hypotonia can be attributed conclusively to peripheral causes ized hypotonia presenting at birth or in early life. Hypotonia represents a . diagnostic challenge because it may be the presentation sign of numerous diseases, as central or peripheral nervous system abnormalities, myopathies, genetic disorders, endocrinopathies, metabolic diseases and acute/chronic illness

Hypotonia - Child Neurology Foundatio

  1. Treatment for Hypotonia and Low Muscle Tone. Prognosis and treatment for low muscle tone depends largely on the underlying cause or condition. In many cases though, occupational therapy, speech therapy, feeding therapy, and other interventions can help
  2. ation. Diagnostic studies are of limited value. Molecular genetics - CTG repeats, deletions in SMN gene Creatine kinase (levels need to be interpreted with caution in th
  3. Neuroneonatology. This book covers the following topics: Clinical Paroxysmal Events, Paroxysmal Motor Events, Apnea, Causes And Treatments Of Seizures, Coma, Generalized Hypotonia, Upper Motor Neuron System Hypotonia, Motor-sensory Unit Hypotonia, Arthrogryposis Multiplex Congenita, Facial Weakness, Decreased Limb Movements, Arm Monoparesis.
  4. g of when the infant developed hypotonia also provides important information. The acute change in his tone makes cerebral dysgenesis, syndromic causes such as Down syndrome or Prader-Willi syndrome, or spinal muscular atrophy less likely. The most common causes of sudden onset hypotonia in a newborn are toxic, metabolic, or infectious
  5. Hypotonia, also called floppy infant syndrome or infantile hypotonia, is a condition of decreased muscle tone. The low muscle tone can be caused by a variety of conditions and is often indicative of the presence of an underlying central nervous system disorder, genetic disorder, or muscle disorder. Muscle tone is the amount of tension or.
  6. Click for pdf: Ataxia GENERAL PRESENTATION Assessing a child who presents with ataxia can be challenging, however with a clear approach and organized differential, the task becomes manageable. Children will present with their parents with the complaint of an abnormal gait and/ or tremor. The ataxic gait is often described as wide based, lurching or [
  7. Fingerprint Dive into the research topics of 'Biallelic loss of OTUD7A causes severe muscular hypotonia, intellectual disability, and seizures'. Together they form a unique fingerprint. Muscle Hypotonia Medicine & Life Science

This collaboration establishes GNAI1 variants as a cause of NDDs. GNAI1-related NDD is most often characterized by severe to profound delays, hypotonia, epilepsy that ranges from self-limiting to. Myoclonic epilepsy involves myoclonic seizures. They are characterized by myoclonic jerks—sudden, unintended muscle contractions. There are several types of myoclonic epilepsy, all of which usually begin during childhood, are typically caused by genetic factors, and may also cause cognitive and developmental problems The most common musculoskeletal effects of Down syndrome include weak muscle tone (hypotonia) and ligaments that are too loose (ligament laxity). This leads to excessive joint flexibility. Joint Instability. Children with Down syndrome may have hip, knee, and other joints that slip out of place or become dislocated. Hip instability

PPT - Neonatal Hypotonia Clinical Approach To Floppy BabyPPT - Ataxia in Children PowerPoint Presentation, freeRhett in his new Stander - Hypotonia Baby - YouTubeDown syndrome featuresSmith-Magenis syndromeJoubert Syndrome
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